Noguchi lab publications (Drexel University College of Medicine, Philadelphia, PA, USA):
62: Peake JD, Noguchi E*.
Fanconi anemia: Current insights regarding epidemiology, Cancer and DNA repair.
Human Genetics, 2022,141(12):1811-1836.

Nacarelli T, Azar A, Potnis M, Johannes G, Mell J, Johnson FB, Brown-Borg H, Noguchi E, Sell C.
The methyltransferase enzymes KMT2D, SETD1B, and ASH1L, are key mediators of both metabolic and epigenetic changes during cellular senescence.
Mol. Biol. Cell, 2022, 33(5):ar36.

Shimonosono M, Tanaka K, Flashner S, Takada S, Matsuura N, Tomita Y, Sachdeva UM, Noguchi E, Sangwan V, Ferri L, Momen-Heravi F, Yoon AJ, Klein-Szanto AJ, Diehl A, Nakagawa H.
Alcohol metabolism enriches squamous cell carcinoma cancer stem cells that survive oxidative stress via autophagy.
Biomolecules, 2021, 11(10), 1479. Open Access.

59: Peake JD,
Noguchi C, Lin B, Theriault A, O'Connor M, Sheth S, Tanaka K, Nakagawa H, Noguchi E*.
FANCD2 limits acetaldehyde-induced genomic instability during DNA replication in esophageal keratinocytes.
Molecular Oncology, 2021, 15(11):3109-3124.
Open Access.

58: Noguchi C, Wang L, Shetty M, Mell JC, Sell C, Noguchi E*.
Maf1 limits RNA polymerase III-directed transcription to preserve genomic integrity and extend lifespan.
Cell Cycle,
2021, 20(3): 247-255. Free in PMC.


57: Chandramouleeswaran PM, Guha M, Shimonosono M, Whelan KA, Maekawa H, Sachdeva UM, Ruthel G, Mukherjee S, Engel N, Gonzalez MV, Garifallou J, Ohashi S, Klei-Szanto AJ, Mesaros CA, Blair IA, Pellegrino da Silva R, Hakonarson H, Noguchi E, Baur JA, Nakagawa H.
Autophagy mitigates ethanol-induced mitochondrial dysfunction and oxidative stress in esophageal keratinocytes.
PLOS ONE, 2020, 15 (9):e0239625 Open Access.

56: Anandarajan V#, Noguchi C#, Oleksak J, Grothusen G, Terlecky D, Noguchi E*.
Genetic investigation of formaldehyde-induced DNA damage response in Schizosaccharomyces pombe.
Current Genetics, 2020, 66(3):593-605

55: Shetty M, Noguchi C, Wilson S, Martinez E, Shiozaki K, Sell C, Mell JC, Noguchi E*.
Maf1-dependent transcriptional regulation of tRNAs prevents genomic instability and is associated with extended lifespan.
Aging Cell, 2020, 19(20):e13068 Open Access.


54: Noguchi C#, Singh T#, Ziegler MA, Peake JD, Khair L, Aza A, Nakamura TM, Noguchi E*.
The NuA4 acetyltransferase and histone H4 acetylation promote replication recovery after topoisomerase I-poisoning.
Epigenetics & Chromatin, 2019, 12(1):24.
Open Access.

Book: DNA Replication Controls (MDPI), Volume 1 and Volume 2.
Editor: Eishi Noguchi.

Online version: A special issue of Genes (Basel): DNA Replication Controls, MDPI, 2016-2017. Open Access.

53: Gadaleta MC, Noguchi E*.
Regulation of DNA replication through natural impediments in the eukaryotic genome.
Genes, 2017, 8(3):98. doi:10.3390/genes8030098
. Open Access.

52: Noguchi C, Grothusen G, Anandarajan V, Martínez-Lage García M, Terlecky D, Corzo K, Tanaka K, Nakagawa H, Noguchi E*.
Genetic controls of DNA damage avoidance in response to acetaldehyde in fission yeast.
Cell Cycle, 2017, 16(1):45-58.
Free in PMC.
* Highlighted by Cell Cycle News & Views. Brooks PJ, Schuebel K. Timeless insights into prevention of acetaldehyde genotoxicity? Cell Cycle, 2017, 16(4): 308-309.

51: Gadaleta MC, González-Medina A, Noguchi E*.
Timeless protection of telomeres.
Current Genetics, 2016, 62(4): 725-730. Free in PMC.

50: Tanaka K, Whelan KA, Chandramouleeswaran PM, Kagawa S, Rustgi SL, Noguchi C, Guha M, Srinivasan S, Amanuma Y, Ohashi S, Muto M, Klein-Szanto AJ, Noguchi E, Avadhani NG, Nakagawa H*.
ALDH2 modulates autophagy flux to regulate acetaldehyde-mediated toxicity thresholds.
Am J Cancer Res, 2016, 6(4): 781-796. Open Access.

49: Gadaleta MC, Das MM, Tanizawa H, Chang Y, Noma K, Nakamura, TM, Noguchi E*.
Swi1Timeless prevents repeat instability at fission yeast telomeres.
PLOS Genetics, 2016, 12(3): e1005943. Open Access.

48: Gadaleta MC, Iwasaki O, Noguchi C, Noma K, Noguchi E*.
Chromatin immunoprecipitation to detect DNA replication and repair factors.
Methods Mol Biol, 2015, 1300: 169-186.
Free in PMC.

Book: Cell Cycle Control: Mechanisms and Protocols, Second Edition.
Editors: Eishi Noguchi & Mariana Gadaleta
A volume of Methods in Molecular Biology, Humana Press/Springer, 2014

47: Leman AR, Noguchi E
Linking chromosome duplication to segregation via sister chromatid cohesion.
Methods Mol Biol, 2014, 1170: 75-98.
Free in PMC.

46: Kriete A, Noguchi E, Sell C.
review of computational cell cycle modeling.
Methods Mol Biol, 2014, 1170: 267-275. Free in PMC.

45: Leman AR, Noguchi E
Chromatin immunoprecipitation to investigate origin association of replication factors in mammalian cells.
Methods Mol Biol, 2014, 1170: 539-547. Free in PMC.

44: Gadaleta MC, Iwasaki O, Noguchi C, Noma K, Noguchi E*.
New vectors for epitope-tagging and gene disruption in Schizosaccharomyces pombe.
BioTechniqeus, 2013, 55(5): 257-263.
Free Article.
The vectors described in this report are avaialbe at Addgene.

43: Roseaulin LC, Noguchi C, Noguchi E*.
Proteasome-dependent degradation of replisome components regulates faithful DNA replication.
Cell Cycle, 2013, 12(16): 2564-2569
. Open Access.

42: Shah N, Inoue A, Lee SW, Beishline K, Lahti JM, Noguchi E*.
Roles of ChlR1 DNA helicase in replication recovery from DNA damage.
Exp Cell Res, 2013, 319(14): 2244-2253.
Free in PMC.

41: Noguchi E*.
PP2ACdc55/B55, a possible therapeutic target in cyclin D1-dependent cancers.
Cell Cycle, 2013, 12(10): 1484-1485. Open Access.

40: Leman AR*, Noguchi E*.
The replication fork: Understanding the eukaryotic replication machinery and the challenges to genome duplication.
Genes, 2013, 4(1): 1-32. Open Access.

39: Roseaulin LC, Noguchi C, Martinez E, Ziegler MA, Toda T, Noguchi E*.
Coodinated degradation of replisome components ensures genome stability upon replication stress in the absence of the replication fork protection complex.
PLoS Genetics, 2013, 9(1): e1003213. Open Access.

38: Tanaka A, Tanizawa H, Sriswasdi S, Iwasaki O, Chatterjee AG, Speicher DW, Levin HL, Noguchi E, Noma K.
Epigenetic regulation of condensin-mediated genome organization during the cell cycle and upon DNA damage through histone H3 lysine 56 acetylation.
Mol Cell, 2012, 48(4): 532-546. Free in PMC.

37: Leman AR, Noguchi E*.
Local and global functions of Timeless and Tipin in replication fork protection.
Cell Cycle, 2012, 11(21): 3945-3955. Open Access.

36: Noguchi C, Rapp JB, Skorobogatko YV, Bailey LD, Noguchi E*.
Swi1 associates with chromatin through the DDT domain and recruits Swi3 to preserve genomic integrity.
PLoS ONE, 2012, 7(8): e43988. Open Access.

35: Leman AR, Dheekollu J, Deng Z, Lee SW, Das MM, Lieberman PM, Noguchi E*.
Timeless preserves telomere length by promoting efficient DNA replication through human telomeres.
Cell Cycle, 2012, 11(12): 2337-2347. Free in PMC.
* Highlighted by Cell Cycle News & Views. Ishikawa F. Timeless tunes: Replicating happy endings. [Cell Cycle, 2012, 11: 2977].
* Listed as a most downloaded article at Cell Cycle and Landes Bioscience! (Ranked in top three: 6/12-6/20)

34: Garabedian MV#, Noguchi C#, Ziegler MA#, Das MM, Singh T, Harper LJ, Leman AR, Khair L, Moser, BA, Nakamura TM, Noguchi E*.
The double-bromodomain factors Bdf1 and Bdf2 modulate chromatin structure to regulate S-phase stress response in Schizosaccharomyces pombe.
GENETICS, 2012, 190(2): 487-500. Free Article.

33: Noguchi E*.
Division of labor of the replication fork protection complex subunits in sister chromatid cohesion and Chk1 activation.
Cell Cycle, 2011, 10(13): 2055-2056. Open Access.

32: Rapp JB#, Noguchi C#, Das MM#, Wong LK, Ansbach AB, Holmes AM, Arcangioli B, Noguchi E*.
Checkpoint-dependent and -independent roles of Swi3 in replication fork recovery and sister chromatid cohesion in fission yeast.
PLoS ONE, 2010, 5(10): e13379. Open Access.

31: Noguchi E*.
The DNA replication checkpoint and preserving genomic integrity during DNA synthesis.
Nature Education, 2010, 3(9): 46. Free Article.

30: Leman AR, Noguchi C, Lee CY, Noguchi E*.
Human Timeless and Tipin stabilize replication forks and facilitate sister chromatid cohesion.
J. Cell Sci., 2010, 123: 660-670. Free Article.

29: Simmoto M, Matsumoto S, Odagiri Y, Noguchi E, Russell P, Masai H*.
Interactions between Swi1-Swi3, Mrc1 and S-phase kinase Hsk1, may regulate DNA replication checkpoint responses in fission yeast.
Genes to Cells, 2009, 14: 669-682.
Free in PMC.

28: Moser BA, Subramanian L, Chang YT, Noguchi C, Noguchi E, Nakamura TM*.
Differential arrival of leading and lagging strand DNA polymerases at fission yeast telomeres.
EMBO J., 2009, 28: 810-820.
Free Article.
* Highlighted by Have you seen...? Price CM. Antics at the telomere: uncoupling polymerases solve the end replication problem [EMBO J, 2009, 28: 795-796].

27: Rapp JB, Ansbach AB, Noguchi C, Noguchi E*.
Chromatin immunoprecipitation of replication factors moving with the replication fork.
Methods Mol. Biol. 2009. 521: 191-202. Free in PMC.

26: Noguchi E*, Ansbach AB, Noguchi C, Russell P.
Assays used to study the replication checkpoint in fission yeast.
Methods Mol. Biol. 2009. 521: 493-507. Free in PMC.

25: Noguchi C, Garabedian M, Malik M, and Noguchi E*.
A vector system for genomic FLAG tagging in Schizosaccharomyces pombe.
Biotechnology Journal, 2008 Oct; 3: 1280-1285.
The vectors described in this report are avaialbe at Addgene.

24: Ansbach AB, Noguchi C, Klansek IW, Heidlebaugh M, Nakamura TM, Noguchi E
RFCCtf18 and the Swi1-Swi3 complex function in separate and redundant pathways required for the stabilization of replication forks to facilitate sister chromatid cohesion in Schizosaccharomyces pombe
Mol. Biol. Cell. 2008 Feb; 19(2): 595-607. Free Article.

23: Noguchi C, Noguchi E*.
Sap1 promotes the association of the replication fork protection complex with chromatin and is involved in the replication checkpoint in Schizosaccharomyces pombe
GENETICS. 2007 Feb;175(2):553-566. Free Article.

22: Coulon S, Noguchi E, Noguchi C, Du L-L, Nakamura MT, Russell P*.
Rad22Rad52-Dependent Repair of Ribosomal DNA Repeats Cleaved by Slx1-Slx4 Endonuclease.
Mol. Biol. Cell. 2006 Apr;17(4):2081-2090. Free Article.

21: Matsumoto S, Ogino K, Noguchi E, Russell P, Masai H*.
Hsk1-Dfp1/Him1, the Cdc7-Dbf4 kinase in Schizosaccharomyces pombe, associates with Swi1, a component of the replication fork protection complex.
J. Biol. Chem. 2005 Dec; 280(52): 42536-42542. Free Article.

Postdoctoral Studies (The Scripps Research Insititute, La Jolla, CA, USA):

20: Noguchi E*, Noguchi C, McDonald WH, Yates III JR, Russell P*.
Swi1 and Swi3 are components of a replication fork protection complex in fission yeast.
Mol. Cell. Biol. 2004 Oct;24(19): 8342-8355. Free Article.

19: Wang Y, Sekiguchi T, Noguchi E, Nishimoto T*.
A hamster temperature-sensitive alanyl-tRNA synthetase mutant causes degradation of cell-cycle related proteins and apoptosis
J. Biochem. (Tokyo). 2004 Jan; 135(1): 7-16. Free in J-STAGE.

18: Zhao H, Tanaka K, Noguchi E, Noguchi C, Russell P*
Replication checkpoint protein Mrc1 is regulated by Rad3 and Tel1 in Fission Yeast
Mol. Cell. Biol. 2003 Nov;23(22): 8395-8403. Free Article.

17: Noguchi E, Noguchi C, Du L-L Russell P*.
Swi1 prevents replication fork collapse and controls checkpoint kinase Cds1
Mol. Cell. Biol. 2003 Nov;23(21): 7861-7874. Free Article.

16: Gaillard PH, Noguchi E, Shanahan P, Russell P*.
The endogenous Mus81-Eme1 complex resolves Holliday Junctions by a nick and counter nick mechanism
Mol. Cell. 2003 Sep;12(3): 747-759. Free Article.

15: Boddy MN, Shanahan P, McDonald WH, Lopez-Girona A, Noguchi E, Yates III JR, Russell P*.
Replication checkpoint kinase cds1 regulates recombinational repair protein rad60.
Mol. Cell. Biol. 2003 Aug;23(16):5939-5946. Free Article.

14: Fukumura J, Noguchi E, Sekiguchi T, Nishimoto T*.
A Temperature-Sensitive Mutant of the Mammalian RNA Helicase, DEAD-BOX X Isoform, DBX, Defective in the Transition from G1 to S Phase.
J. Biochem. (Tokyo). 2003 Jul;134(1):71-82. Free in J-STAGE.

13: Noguchi E, Shanahan P, Noguchi C, Russell P*.
CDK Phosphorylation of Drc1 Regulates DNA Replication in Fission Yeast.
Curr. Biol. 2002 Apr 2;12(7):599-605. Free Article.

Graduate Studies (Kyushu University, Fukuoka, Japan):

12: Suzuki N, Noguchi E, Nakashima N, Oki M, Ohba T, Tartakoff A, Ohishi M, Nishimoto T*.
The Saccharomyces cerevisiae small GTPase, Gsp1p/Ran, is involved in 3' processing of 7S-to-5.8S rRNA and in degradation of the excised 5'-A0 fragment of 35S pre-rRNA, both of which are carried out by the exosome.
GENETICS. 2001 Jun;158(2):613-625. Free Article.

11: Nakashima N, Noguchi E, Nishimoto T*.
Saccharomyces cerevisiae putative G protein, Gtr1p, which forms complexes with itself and a novel protein designated as Gtr2p, negatively regulates the Ran/Gsp1p G protein cycle through Gtr2p.
GENETICS. 1999 Jul;152(3): 853-867. Free Article.

10: Noguchi E, Saitoh Y, Sazer S, Nishimoto T*.
Disruption of the YRB2 gene retards nuclear protein export, causing a profound mitotic delay, and can be rescued by overexpression of XPO1/CRM1.
J. Biochem. (Tokyo). 1999 Mar;125(3):574-585. Free in J-STAGE.

9: Shiomi T, Fukushima K, Suzuki N, Nakashima N, Noguchi E, Nishimoto T*.
Human dis3p, which binds to either GTP- or GDP-Ran, complements Saccharomyces cerevisiae dis3.
J. Biochem. (Tokyo).1998 May;123(5):883-890. Free in J-STAGE.

8: Oki M, Noguchi E, Hayashi N, Nishimoto T*.
Nuclear protein import, but not mRNA export, is defective in all Saccharomyces cerevisiae mutants that produce temperature-sensitive forms of the Ran GTPase homologue Gsp1p.
Mol. Gen. Genet. 1998 Apr;257(6):624-634.

7: Noguchi E, Hayashi N, Nakashima N, Nishimoto T*.
Yrb2p, a Nup2p-related yeast protein, has a functional overlap with Rna1p, a yeast Ran-GTPase-activating protein.
Mol. Cell. Biol. 1997 Apr;17(4):2235-2246. Free Article.

6: Noguchi E, Hayashi N, Azuma Y, Seki T, Nakamura M, Nakashima N, Yanagida M, He X, Mueller U, Sazer S, Nishimoto T*.
Dis3, implicated in mitotic control, binds directly to Ran and enhances the GEF activity of RCC1.
EMBO J. 1996 Oct 15;15(20):5595-5605. Free in PMC.

5: Nakashima N, Hayashi N, Noguchi E, Nishimoto T*.
Putative GTPase Gtr1p genetically interacts with the RanGTPase cycle in Saccharomyces cerevisiae.
J. Cell Sci. 1996 Sep;109 (Pt 9):2311-2318. Free Article.

4: Sekiguchi T*, Noguchi E, Hayashida T, Nakashima T, Toyoshima H, Nishimoto T, Hunter T*.
D-type cyclin expression is decreased and p21 and p27 CDK inhibitor expression is increased when tsBN462 CCG1/TAFII250 mutant cells arrest in G1 at the restrictive temperature.
Genes Cells. 1996 Jul;1(7):687-705.

3: Noguchi E, Sekiguchi T, Nohiro Y, Hayashida T, Hirose E, Hayashi N, Nishimoto T*.
Minimum essential region of CCG1/TAFII250 required for complementing the temperature-sensitive cell cycle mutants, tsBN462 and ts13 cells, of hamster BHK21 cells.
Somat. Cell Mol. Genet. 1994 Nov;20(6):505-513.

2: Hayashida T, Sekiguchi T, Noguchi E, Sunamoto H, Ohba T, Nishimoto T*.
The CCG1/TAFII250 gene is mutated in thermosensitive G1 mutants of the BHK21 cell line derived from golden hamster.
Gene. 1994 Apr 20;141(2):267-270.

1: Noguchi E, Sekiguchi T, Yamashita K, Nishimoto T*.
Molecular cloning and identification of two types of hamster cyclin-dependent kinases: cdk2 and cdk2L.
Biochem. Biophys. Res. Commun. 1993 Dec 30;197(3):1524-1529.

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