Welcome to our group!

NEWS:
Our new manuscript, "Maf1 limits RNA polymerase III-directed transcription to preserve genomic integrity and extend lifespan" has been accepted for publication in Cell Cycle!
The authors are: Chiaki Noguchi, Lucy Wang, Mihir Shetty, Joshua Mell, Christian Sell, and Eishi Noguchi.
Lucy was a high school student when she contributed to this work!

GENOME MAINTENANCE MECHANISMS, CANCER, AND AGING:
Genomic instability is a hallmark of cancers and age-relatd diseases. Our long-term goal is to understand how cells maintain genomic integrity to regulate lifespan and avoid tumorigenesis. Emerging evidence suggests that a variety of environmental factors and toxins damage DNA, leading to an arrest of the DNA replication fork, the actual site of DNA synthesis. Arrested replication forks are prone to collapse, posing serious threats to genomic integrity, suggesting that DNA replication problems are critical drivers of genomic instability that promotes aging and tumorigenesis.

OUR APPROACHES
The Noguchi lab works with mammalian cells and fission yeast (Schizosaccharomyces pombe). Fission yeast is an exceptional model system for studying cell cycle control and genome maintenance mechanisms that are highly conserved amongst most eukaryotes, including humans. Our general approach defines principles and identifies important proteins in fission yeast and then determines whether human homologues of these proteins have related function using mammalian cell culture. Our current research projects include:

  • Identify and investigate the mechanisms of DNA replication at difficult-to-replicate chromosomal regions.
  • Investigate the mechanisms of alcohol-mediated genomic instability and esophageal carcinogenesis.
  • Investigate the genetic mechanisms that govern lifespan extension by preserving genomic integrity.
Environmental factors or even our metabolism can cause DNA damage during DNA replication, leading to genomic instability, which is a hallmark of cancer and aging. Therefore, our research projects will provide a framework for guiding investigations that will greatly impact the biology of cancer and aging.

What is Fission yeast? Fission yeast is highly amenable to genetic and biochemical analyses to understand basic cellular functions. Wide variety of genetic manipulations available in fission yeast readily allow you to determine functions of genes and proteins involved. Since many of cellular mechanisms in Fission yeast are similar to those of humans, the information quickly obtained by yeast studies can be extrapolate to human systems.


The cell cycle checkpoints Teaching and Administration T-shirt
Our research projects Publication List Protocols
What is Fission yeast (S. pombe)? Search Tools Links


Availabe from Amazon


DNA Replication Contols
Volume I (Amazon)
Volume II (Amazon)

Our research has been funded by grants from:
---Leukemia Research Foundation (2006-2007)
---Pennsylvania Department of Health (2007-2008; 2016-2018; 2020-2022)
---W. W. Smith Charitable Trust (2007-2008; 2018-2020; 2021-2022)
---National Institute of General Medical Sciences: NIH-NIGMS (2008--2019)
---Recovery Act of 2009: NIH-NIGMS (2009-2011)
---National Institute on Aging: NIH-NIA (2009-2012)
---The Aging Initiative at Drexel University College of Medicine (2008-2011; 2013-2015)

---National Institute on Alcohol Abuse and Alcoholism: NIH-NIAAA (2018-2020)

Awards and Honors:

2020
Jasmine Peake
Top Poster at 2020 DNA Damage, Mutation and Cancer: Gordon Research Conference

Eishi Noguchi
The W. W. Smith Charitable Trust Award for Cancer Research

2019
Jasmine Peake
2019 Southern Regional Education Board State Doctoral Scholar Award
2019 Drexel Graduate Student Mentorship Award
2019 College of Medicine Common good Award

Ruchi Patel
Drexel Discovery Day 2019, 3rd Place, Undergraduate Student Poster

Eishi Noguchi
Invited for platform presentation, International Fission Yeast Meeting (Pombe 2019)
Co-Investigator, PA CURE Formula Funds, PI: Christian Sell

2018
Jasmine Peake
Drexel Discovery Day 2018, Platform presentation
NIH-F31 Predoctoral Fellowship

Ruchi Patel
Drexel Discovery Day 2018, 3rd Place, Undergraduate Student Poster

Erik Serrano
Cal State-SURF 2018, Summer Undergraduate Research

Eishi Noguchi
The W. W. Smith Charitable Trust Award for Cancer Research
Selected for platform presentation, Molecular Biology Society of Japan Annual Meeting

2017
Jasmine Peake
NIH Diversity Supplements
Drexel Discovery Day 2017, 2nd place, Senior Graduate Student Poster
Career Day, Chestnutwold Elementary

Eishi Noguchi
Selected for platform presentation, International Fission Yeast Meeting (Pombe 2017)
Selected for platform presentation, Molecular Biology Society of Japan Annual Meeting

2016
Jasmine Peake
Honorable Mention, Ford Foundation

Mihir Shetty

2016 MS Award for Excellence in Research

Sydney Wilson
Drexel Discovery Day 2016, 2nd place, Undergraduate Student Poster

Lainey Barber
DUCOM-SURF 2016, Summer Undergraduate Research

Eishi Noguchi
PA CURE Formula Funds

2015
Mariana Gadaleta
DUCOM Aging Initiative, Graduate Fellowship
Drexel Discovery Day 2015, 2nd place, Postdoc Poster
Selected for platform presentation, International Fission Yeast Meeting (Pombe 2015)

Eishi Noguchi
Selected for platform presentation, International Fission Yeast Meeting (Pombe 2015)

2014
Mariana Gadaleta
Drexel Discovery Day 2014, 3rd place, Senior Graduate Student Poster

Emily Ortega
DUCOM-Med Student Summer Research 2014

Grant Grothusen
Drexel Research Day 2014, 1st place, Undergraduate

2013
Mariana Gadaleta
Selected for platform presentation, Keystone Symposia/DNA Replication and Recombination
Selected for platform presentation, New York Academy of Sciences, Genome Integrity
DUCOM-GSA Travel Award

Gregory Dickinson
DUCOM-Med Student Summer Research 2013

Jordan Asam
DUCOM-SURF 2013, Summer Undergraduate Research

Eishi Noguchi
DUCOM Aging Initiative Grant
Co-Investigator, NIH-R01, PI: Karen Berkowitz
Selected for platform presentation, ASBMB EB 2013
Selected for platform presentation, Cold Spring Harbor Meeting/Eukaryotic DNA replication
Invited platform presentation, Message from yeast to epigenetics

2012
Esteban Martinez
NIGMS/NIH Diversity Supplements
Drexel Discovery Day 2012, 3rd place, Undergraduate Student Postr

Rochelle Volmerding
DUCOM-SURF 2012, Summer Undergraduate Research

2011
Mariana Gadaleta
Selected for platform presentation, Drexel Discovery Day

Rochelle Volmerding
DUCOM-SURF 2011, Summer Undergraduate Research

Lucy Wang
DUCOM-HSSRI 2011, Summer High School Research

Eishi Noguchi
Selected for platform presentation, International Fission Yeast Meeting (Pombe 2011)

2010
Laura Roseaulin
Drexel Discovery Day 2010, Honorable mention, Postdoc Poster

Adam Leman
Drexel Discovery Day 2010, 2nd place, Platform presentation

Karen Shen
DUCOM-SURF 2010, Summer Undergraduate Research
Drexel Discovery Day 2010, 1st place, Undergraduate Student Poster

Esteban Martinez
Drexel Discovery Day 2010, 2nd place, Undergraduate Student Poster

Melissa Ziegler
Drexel Discovery Day 2010, 2nd place, Technician Poster

Carlos Dominguez
Goya Mundus fellowship

Eishi Noguchi
Drexel University Co-op grant

2009
Adam Leman
NIH-F31 Predoctoral Fellowship
Drexel Discovery Day 2009, 1st place, Senior Graduate Student
Selected for platform presentation, Cold Spring Harbor Meeting/Eukaryotic DNA replication

Jordan Rapp
DUCOM-Med Student Summer Research 2009
Drexel Discovery Day 2009, 3rd place, Medical Student

Mercedes Ramirez
Goya Mundus fellowship
Drexel Discovery Day 2009, Honorable mention, Undergraduate

Logan Harper
DUCOM-SURF 2009, Summer Undergraduate Research

Mikael Garabedian
CoAS Research Day 2009, 2nd place, Undergraduate

Eishi Noguchi
Young Investigator Award
ARRA-NIH-R01 supplements

2008
Adam Leman
DUCOM Aging Initiative, Graduate Fellowship
Drexel Discovery Day 2008, Honorable mention, Graduate Student
Selected for platform presentation, Buffalo DNA replication and Repair Symposium

Jordan Rapp
Drexel Discovery Day 2008, Honorable mention, Medical Student

Mikael Garabedian
Drexel Discovery Day 2008, 2nd place, Undergraduate

Logan Harper
DUCOM-SURF 2008, Summer Undergraduate Research
Drexel Discovery Day 2008, Honorable mention, Undergraduate

Eishi Noguchi
NIH-R01

2007
Adam Leman
Drexel Discovery Day 2007, Honorable mention, Platform presentation
RICS Day 2007, 1st place, Graduate Student

Ana Aza
Drexel Discovery Day 2007, 1st place, Undergraduate

Eishi Noguchi
Research Fellowship From W.W. Smith Charitable Trust
PA Translational Foundation Grant
Selected for platform presentation, Cold Spring Harbor Meeting/Eukaryotic DNA replication

2006
Eishi Noguchi
New Investigator Award, Leukemia Research Foundation
Selected for platform presentation,
Salk/Caltech Meeting on DNA replication/Genome Integrity

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Eishi Noguchi