Welcome to our group!

GENOME MAINTENANCE MECHANISMS, CANCER, AND AGING:
Genomic instability is a hallmark of cancers and age-relatd diseases. Our long-term goal is to understand how cells maintain genomic integrity to regulate lifespan and avoid tumorigenesis. Emerging evidence suggests that a variety of environmental factors and toxins damage DNA, leading to an arrest of the DNA replication fork, the actual site of DNA synthesis. Arrested replication forks are prone to collapse, posing serious threats to genomic integrity, suggesting that DNA replication problems are critical drivers of genomic instability that promotes aging and tumorigenesis.

OUR APPROACHES
The Noguchi lab works with mammalian cells and fission yeast (Schizosaccharomyces pombe). Fission yeast is an exceptional model system for studying cell cycle control and genome maintenance mechanisms that are highly conserved amongst most eukaryotes, including humans. Our general approach defines principles and identifies important proteins in fission yeast and then determines whether human homologues of these proteins have related function using mammalian cell culture. Our current research projects include:

  • Identify and investigate the mechanisms of DNA replication at difficult-to-replicate chromosomal regions.
  • Investigate the mechanisms of alcohol-mediated genomic instability and esophageal carcinogenesis.
  • Investigate the genetic mechanisms that govern lifespan extension by preserving genomic integrity.
Environmental factors or even our metabolism can cause DNA damage during DNA replication, leading to genomic instability, which is a hallmark of cancer and aging. Therefore, our research projects will provide a framework for guiding investigations that will greatly impact the biology of cancer and aging.

What is Fission yeast? Fission yeast is highly amenable to genetic and biochemical analyses to understand basic cellular functions. Wide variety of genetic manipulations available in fission yeast readily allow you to determine functions of genes and proteins involved. Since many of cellular mechanisms in Fission yeast are similar to those of humans, the information quickly obtained by yeast studies can be extrapolate to human systems.


The cell cycle checkpoints Teaching and Administration T-shirt
Our research projects Publication List Protocols
What is Fission yeast (S. pombe)? Search Tools Links


Availabe from Amazon


Special Issue "DNA Replication Contols"

Our research has been funded by grants from:
---Leukemia Research Foundation (2006-2007)
---Pennsylvania Department of Health (2007-2008 & 2016-2017)
---W. W. Smith Charitable Trust (2007-2008)
---National Institute of General Medical Sciences: NIH-NIGMS (2008-2014)
---Recovery Act of 2009: NIH-NIGMS (2009-2011)
---National Institute on Aging: NIH-NIA (2009-2012)
---Drexl University Co-op Undergraduate Research Program (2010)
---The Aging Initiative at Drexel University College of Medicine (2008-2011 & 2013-2015)

Awards and Honors:

Year Prizes/Honors/Platform Presentation Fellowships/Grants
2017

Jasmine Peake: Career Day, Chesnutwold Elementary School

Jasmine Peake (NIH Diversity Supplements/Berkowitz-Noguchi)
2016

Mihir Shetty: 2016 MS Award for Excellence in Research
Jasmine Peake: 2016 Honorable Mention, Ford Foundation

Drexel Discovery Day 2016
Sydney Wilson (2nd place, Outstanding Undergraduate Poster)

Eishi Noguchi (DUCOM CURE Formula Funds)
Lainey Barber (DUCOM-SURF 2016, Summer Undergraduate Research)
2015 Drexel Discovery Day 2015
Mariana Gadaleta (2nd place, Postdoc)

International Fission Yeast Meeting (Pombe 2015)

Mariana Gadaleta (Selected for platform presentation)
International Fission Yeast Meeting (Pombe 2015)
Eishi Noguchi (Selected for platform presentation)
Mariana Gadaleta (DUCOM Aging Initiative, Graduate Fellowship)
2014 Drexel Research Day 2014
Grant Grothusen (1st place, Undergraduate)
Drexel Discovery Day 2014
Mariana Gadaleta (3rd place, Senior Graduate Student)
Emily Ortega (DUCOM-Med Student Summer Research 2014)
2013

Keystone Symposia/DNA Replication and Rcombination
Mariana Gadaleta (Selected for platform presentation)
New York Academy of Sciences, Genome Integrity
Mariana Gadaleta (Selected for platform presentation)

ASBMB EB 2013
Eishi Noguchi (Selected for platform presentation)
Cold Spring Harbor Meeting/Eukaryotic DNA replication
Eishi Noguchi (Selected for platform presentation)

Message from yeast to epigenetics
Eishi Noguchi (Invited platform presentation)


Mariana Gadaleta (DUCOM-GSA Travel Award)
Jordan Asam (DUCOM-SURF 2013, Summer Undergraduate Research)
Gregory Dickinson (DUCOM-Med Student Summer Research 2014)

Eishi Noguchi (DUCOM Aging Initiative, Small Grant)
2012 Drexel Discovery Day 2012
Esteban Martinez (3rd place, Undergraduate)
Esteban Martinez/Eishi Noguchi (NIGMS/NIH Diversity Supplements)
Rochelle Volmerding (DUCOM-SURF 2012, Summer Undergraduate Research)
2011 Drexel Discovery Day 2011
Mariana
Gadaleta (Selected for platform presentation)
International Fission Yeast Meeting (Pombe 2011)
Eishi Noguchi
(Selected for platform presentation)
Rochelle Volmerding (DUCOM-SURF 2011, Summer Undergraduate Research)
Lucy Wang (DUCOM-HSSRI 2011, Summer High School Research)
2010 Drexel Discovery Day 2010
Karen Shen (1st place, Undergraduate)
Adam Leman (2nd place, Platform presentation)
Esteban Martinez (2nd place, Undergraduate)
Melissa Ziegler (2nd place, Technician)
Laura Roseaulin (Honorable mention, Postdoc)
Carlos Dominguez (Goya Mundus fellowship)
Karen Shen
(DUCOM-SURF 2010, Summer Undergraduate Research)
Eishi Noguchi (Drexel University Co-op grant)
2009 Drexel Discovery Day 2009
Adam Leman (1st place, Senior Graduate Student)
Jordan Rapp (3rd place, Medical Student)
Mercedes Ramirez (Honorable mention, Undergraduate)
Eishi Noguchi (Young Investigator Award)
CoAS Research Day 2009
Mikael Garabedian (2nd place, Undergraduate)
Cold Spring Harbor Meeting/Eukaryotic DNA replication
Adam Leman (Selected for platform presentation)
Adam Leman (NIH-F31 Predoctoral Fellowship)
Jordan Rapp (DUCOM-Med Student Summer Research 2009)
Mercedes Ramirez (Goya Mundus fellowship)
Logan Harper (DUCOM-SURF 2009, Summer Undergraduate Research)
Eishi Noguchi (ARRA-NIH-R01 supplements)
2008

Drexel Discovery Day 2008
Mikael Garabedian (2nd place, Undergraduate)
Adam Leman
(Honorable mention, Graduate Student)
Jordan Rapp (Honorable mention, Medical Student)
Logan Harper (Honorable mention, Undergraduate)
Buffalo DNA replication and Repair Symposium
Adam Leman (Selected for platform presentation)

Adam Leman (DUCOM Aging Initiative, Ggraduate Fellowship)
Logan Harper (DUCOM-SURF 2008, Summer Undergraduate Research)
Eishi Noguchi (NIH-R01)
2007

Drexel Discovery Day 2007
Ana Aza (1st place, Undergraduate)
Adam Leman (Honorable mention, Platform presentation)
RICS Day 2007
Adam Leman (1st place, Graduate Student)
Cold Spring Harbor Meeting/Eukaryotic DNA replication
Eishi Noguchi (Selected for platform presentation)

Eishi Noguchi (Research Fellowship From W.W. Smith Charitable Trust)
Eishi Noguchi (DUCOM Translational Foundation Grant)
2006 Salk/Caltech Meeting on DNA replication/Genome Integrity
Eishi Noguchi (Selected for platform presentation)
Eishi Noguchi (New Investigator Award, Leukemia Research Foundation)

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Eishi Noguchi